Recombinant liveSalmonellaspp. for human vaccination against heterologous pathogens
Open Access
- 1 April 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in FEMS Immunology & Medical Microbiology
- Vol. 27 (4) , 357-364
- https://doi.org/10.1111/j.1574-695x.2000.tb01450.x
Abstract
Live attenuated Salmonella spp. are promising candidates as oral vaccine delivery systems for heterologous antigens. Clinical trials have demonstrated that this approach is feasible for human vaccinations but further optimisation is necessary to obtain a better efficacy. Here, we discuss how existing clinical and pre-clinical data can be used to guide such optimisation efforts.Keywords
This publication has 35 references indexed in Scilit:
- Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.Journal of Clinical Investigation, 1998
- Impairment of Mycobacterial Immunity in Human Interleukin-12 Receptor DeficiencyScience, 1998
- Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient PatientsScience, 1998
- Salmonella typhi Vaccine Strain CVD 908 Expressing the Circumsporozoite Protein of Plasmodium falciparum: Strain Construction and Safety and Immunogenicity in HumansThe Journal of Infectious Diseases, 1994
- Construction of plasmid vectors with a non-antibiotic selection system based on the Escherichia coli thyA+ gene: application to cholera vaccine developmentGene, 1991
- The role of a stress‐response protein in Salmonella typhimurium virulenceMolecular Microbiology, 1991
- Efficacy of one or two doses of Ty21a Salmonella typhi vaccine in enteric-coated capsules in a controlled field trialVaccine, 1990
- Prevention of Shigellosis by a Salmonella typhi-Shigella sonnei Bivalent VaccineThe Journal of Infectious Diseases, 1987
- Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccinesNature, 1981
- Evaluation of a UDP-Glucose-4-Epimeraseless Mutant of Salmonella typhi as a Live Oral VaccineThe Journal of Infectious Diseases, 1977