THIAMINE OVERDOSAGE AND TOXICITY

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To the Editor:— The use of thiamine hydrochloride, through both lay and medical channels, has reached large proportions. With inferential evidence only regarding human requirements for the maintenance of good health, and without any published evidence of toxicity, the tendency has been toward an intake well above established deficiency levels. Williams and his associates (Williams, R. D.; Mason, H. L.; Wilder, R. M., and Smith, B. F.: Observations on Induced Thiamine Deficiency in Man,Arch. Int. Med.66:785 [Oct.] 1940) showed that definite deficiency symptoms would develop in otherwise normal adults kept on a daily intake of 0.15 mg. for several months, while it is generally presumed that 2 to 3 mg. daily will cover the normal adult needs in health. Little evidence has been presented, however, to show just how much the daily intake need be increased in patients suffering from long-standing deficiency. Here again the tendency has

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