THE TOXICITY OF SODIUM ALGINATE IN CATS
- 1 June 1948
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 127 (6) , 1173-1181
- https://doi.org/10.1097/00000658-194806000-00006
Abstract
The intraperitoneal or intravenous injection in cats of solutions of sodium alignate results in the production of large ante-mortem intracardiac clots. Evidence is presented that injury to the brain, liver and kidney frequently occurs. Alginic acid shares with other gums the ability to accelerate the sedimentation of erythrocytes. A di-aldehyde derivative of alginic acid is slightly less toxic than alginic acid while a nitrated derivative is more toxic and in addition greatly prolongs clotting time in vivo.Keywords
This publication has 1 reference indexed in Scilit:
- EXPERIMENTAL OBSERVATIONS ON ABSORBABLE ALGINATE PRODUCTS IN SURGERY*Annals of Surgery, 1947