ISOLATION, AMINO ACID SEQUENCE AND ACTION OF GUINEA-PIG ACTH ON ALDOSTERONE PRODUCTION BY GLOMERULOSA CELLS
- 1 November 1987
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 115 (2) , R5-R8
- https://doi.org/10.1677/joe.0.115r005
Abstract
Though minor sequence differences between-species have been reported for adrenocorticotrophin, ACTH(1–39), the steroidogenic moiety ACTH(1–24) has appeared invariant in mammals. We here report the isolation, purification and amino acid sequencing of guinea-pig (GP) ACTH in which Pro24 is replaced by [ill] Ala24, and the demonstration that GP-ACTH stimulates aldosterone production to maximal levels well above those seen with human ACTH(1–39) or Synacthen, ACTH(1–24) amide, the synthetic ACTH fragment widely used for diagnostic and therapeutic purposes.This publication has 20 references indexed in Scilit:
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