Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.
Open Access
- 15 February 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 152 (4) , 1751-1755
- https://doi.org/10.4049/jimmunol.152.4.1751
Abstract
The Fas Ag and the p55 TNF receptor (TNF-R1) are related molecules that can signal apoptosis. Some tumor cell lines are selectively killed by Fas activation and others by TNF-R1 activation even though both receptors are often co-expressed. TNF-R1-mediated cytotoxicity can be selectively inhibited under conditions in which Fas-mediated cell death is not affected. Activation of both receptors results in synergistic signaling of apoptosis. These results indicate that different biochemical pathways are activated by Fas and TNF-R1. Combination treatment with agonists of Fas and TNF-R1 may have therapeutic potential.This publication has 0 references indexed in Scilit: