ANAPHYLAXIS TO SUXAMETHONIUM: A Case Report

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Abstract
Two severe reactions to suxamethonium occurred in a 26-year-old woman with an “allergic diathesis” but who had no previous exposure to suxamethonium. The diagnosis of anaphylaxis was supported clinically by the immediate onset of tachycardia, hypotension, bronchospasm, pharyngeal and facial oedema, and immunologically by the demonstration of immediate reagin-type cutaneous hypersensitivity reactions to suxamethonium, and a positive passive transfer (Prausnitz-Küstner) reaction. Suxamethonium can cause histamine release: this could explain previously reported cases of “sensitivity” to suxamethonium. Our case was considered to be true anaphylaxis.

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