EFFECTS OF ENDOTOXIN-TOLERANCE ON INVIVO DRUG-METABOLISM IN MICE
- 1 January 1980
- journal article
- research article
- Vol. 29 (1) , 193-196
Abstract
Acute doses of endotoxin and the induction of endotoxin-tolerance lowered the apparent in vivo rates of hexobarbital and zoxazolamine metabolism in mice. Acute doses of endotoxin increased the duration of narcosis induced by these 2 compounds to a greater extent than did induction of the endotoxin-tolerant state. In endotoxin-tolerant mice, acute endotoxin treatment did not extend hexobarbital sleeping or zoxazolamine paralysis times beyond those noted in endotoxin-tolerant mice given no acute endotoxin.This publication has 7 references indexed in Scilit:
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