EFFECTS OF ENDOTOXIN-TOLERANCE ON INVIVO DRUG-METABOLISM IN MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 29  (1) , 193-196
Abstract
Acute doses of endotoxin and the induction of endotoxin-tolerance lowered the apparent in vivo rates of hexobarbital and zoxazolamine metabolism in mice. Acute doses of endotoxin increased the duration of narcosis induced by these 2 compounds to a greater extent than did induction of the endotoxin-tolerant state. In endotoxin-tolerant mice, acute endotoxin treatment did not extend hexobarbital sleeping or zoxazolamine paralysis times beyond those noted in endotoxin-tolerant mice given no acute endotoxin.