Choline Acetyltransferase Activity in Postganglionic Parasympathetic Nerves after “Pharmacological Decentralization”

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Abstract
The ganglion blocking drug chlorisondamine given frequently and in gradually increasing doses over a period of time to adult rats causes the activity of choline acetyltransferase to fall in the postganglionic parasympathetic nerves of parotid glands. Such a "pharmacologically" decentralized gland was also found to have lost weight and to have developed a supersensitivity to chemical stimuli. All these phenomena are thought to be consequences of loss or reduction of secretory impulses from the CNS due to impaired ganglionic transmission.