Prostaglandin analogs possessing antinidatory effects. 1. Modification of the .omega. chain
- 1 May 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (5) , 519-524
- https://doi.org/10.1021/jm00179a010
Abstract
Novel prostaglandin [PG] analog modified in the .omega. chain were prepared by the reaction of the vinyl aldehydes with a variety of organometallic reagents as a key step of the synthesis. Compared with the natural PGF2.alpha. in antinidatory effect, the analogs 17-oxo-17-phenyl-18,19,20-trinorprostaglandin F2.alpha. methyl ester, 16,16,17,17-tetrahydro-17-phenyl-18,19,20-trinorprostaglandin F2.alpha. methyl ester and 15-(2-benzo[b]thienyl)-16,17,18,19,20-pentanorprostaglandin F2.alpha. methyl ester were 40 times more potent and 15-(2-benzofuranyl)-16,17,18,19,20-pentanorprostaglandin F2.alpha. methyl ester was 50-100 times more potent in the rat.This publication has 1 reference indexed in Scilit:
- Prostaglandin E1: Studies on Antifertility and Luteolytic Effects in Hamsters and RatsBiology of Reproduction, 1973