Possible Central Action of Certain Vasoactive Agents

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Abstract
A previously reported ‘cerebral chemoreceptor buffer mechanism’ was investigated by means of the cross-circulated, vascularly isolated dog head preparation. With the carotid sinuses deactivated, the response of the body blood pressure to centrally circulating vasoactive agents was recorded. When high concentrations of these agents were administered to the isolated head, changes in body blood pressure were frequently observed. However, these changes bore no consistent relation to the blood pressure response of the isolated head or of the intact animal. The body blood pressure response to the central action of these agents was trivial in comparison with the consistent reciprocal response mediated by them through the carotid sinus mechanism.