Localization of interleukin 6 mRNA in human tonsils by in situ hybridization
- 1 December 1989
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 19 (12) , 2379-2381
- https://doi.org/10.1002/eji.1830191230
Abstract
We have investigated which areas produce interleukin 6 (IL 6) in human tonsils. This growth factor is required for the terminal differentiation of B lymphocytes into plasmocytes. Using 35S‐labeled IL 6 cDNA we demonstrated IL 6 gene expression over various areas of the tonsils, with consistent exception of the follicles, by in situ hybridization. It is, therefore, proposed that B cells are stimulated during their migration out of the follicles.This publication has 14 references indexed in Scilit:
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