Sulphate formation from dimethylthetin in rat liver

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Abstract
Dimethylthetin chloride incubated with rat liver or kidney slices in either bicarbonate or phosfate salines was not oxidized to sulfate, but the compound incubated with homocysteine gave rise to a larger amount of sulfate than was obtained with homocysteine alone. Methylthioacetic acid was oxidized to sulfate by liver slices and to a lesser extent by kidney slices. Ethylthioacetic, mercapto-acetic and dithio-diglycollic acids were also oxidized by liver slices, whereas S-phenylthioacetic acid was not. Suspensions of fresh liver on acetone-dried liver powders were unable to oxidize methylthioacetic acid. Addition of the following reagents singly, in groups, or altogether did not restore the oxidatlve ability of the tissue: MgCl2, MnCl2, glucose, diphosphopyridine nucleotide, cytochrome c and adeno-sine 5-phosphate with sodium fumarate.