Leucine-Induced Hypoglycemia

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Abstract
SPONTANEOUS hypoglycemia in infancy may, on rare occasions, be precipitated by the ingestion of casein, L-leucine or isovaleric acid, an intermediary metabolite of leucine.1 2 3 4 Recently, this phenomenon of "leucine-induced hypoglycemia" was observed to be associated with a rise in plasma insulin level.5 , 6 A case of leucine-induced hypoglycemia in an infant who, at autopsy, showed hyperplasia of pancreatic islet cells is reported below. In addition the patient had massive bilateral subdural hematomas, with cerebral atrophy.Case ReportP.C., a 3 1/2-month-old female Negro infant, was admitted to the Clinical Center of the National Institutes of Health on July 13, 1959, because . . .