Familial polyposis
- 1 January 1977
- Vol. 39 (1) , 267-273
- https://doi.org/10.1002/1097-0142(197701)39:1<267::aid-cncr2820390141>3.0.co;2-x
Abstract
Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adeno-carcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other genetically-linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow-up and intensive surveillance of non-polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of view, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.Keywords
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