Muscle Relaxing Activity of Hyssopus officinalis Essential Oil on Isolated Intestinal Preparations
- 25 March 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 68 (3) , 213-216
- https://doi.org/10.1055/s-2002-23139
Abstract
The muscle relaxing activity of the essential oil of Hyssopus officinalis L. (Lamiaceae) and some of its main components (isopinocamphone, limonene and β-pinene) was studied on isolated preparations of guinea-pig and rabbit intestine. The essential oil and isopinocamphone inhibited the acetylcholine- and BaCl2-induced contractions in guinea-pig ileum in a concentration-dependent manner (IC50 42.4 μg/ml and 61.9 μg/ml to acetylcholine; 48.3 μg/ml and 70.4 μg/ml to BaCl2) whereas limonene or β-pinene left tissue contraction unchanged. In guinea-pig ileum H. officinalis essential oil also blocked the contractions induced by CaCl2. In isolated rabbit jejunum the essential oil reduced the amplitude of spontaneous movements and decreased the basal tone; neither haemoglobin, methylene blue, N ω-nitro-L-arginine methyl ester (L-NAME) or propranolol blocked the myorelaxant effect.Keywords
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