Changes in Serum and Urinary Amino Acids after the Administration of a Mixed Beta-Adrenergic Agonist

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Abstract
The administration of the repartitioning agent metaproterenol, with affinity for beta 1- and beta 2-receptors, induced marked increases in gastrocnemius muscle and heart weights. The renal loss of essential amino acids was reduced in animals treated with beta-adrenergic agonists and a significant reduction in total serum amino acids was found as well. The assessment of urinary 3-methylhistidine suggests, that those changes were accompanied by a lower myofibrillar protein breakdown, while hydroxyproline output was increased as an indirect index of collagen turnover.

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