Yeuhchukene—An Indole Derivative Interacting with Guinea Pig Reproduction

1 January 1990

journal article
research article
Published by World Scientific Pub Co Pte Ltd in The American Journal of Chinese Medicine

Vol. 18 (01n02) , 1-4
https://doi.org/10.1142/s0192415x90000022

Abstract

Natural yuehchukene in doses of 10mg/kg/day induced a 40% reduction of pregrancies in the guinea pig as compared with controls (p). Yuehchukene also caused a reduction in litter size which, however, was not significant indicating limited toxicity of the drug. An inhibition of ovum fertilization and/or implantation is suggested as the mechanism of action.

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