Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
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- 10 February 2008
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 40 (3) , 281-283
- https://doi.org/10.1038/ng.89
Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 × 10−13 and 7.7 × 10−9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.Keywords
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