TREATMENT OF ULCERATIVE COLITIS WITH CORTICOTROPIN (ACTH) AND CORTISONE

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Abstract
The purpose of this communication is to report our experiences over a period of 2 years with the use of corticotropin (ACTH) and cortisone in a selected group of patients with ulcerative colitis. Studies were directed to determine the effectiveness of hormone therapy in inducing a remission in the disease. The possibility of sustaining the remission by long-term maintenance therapy and repeated courses of hormone treatment was investigated. Corticotropin therapy was begun in the first patient of this series (O. D.) on Oct. 2, 1949. The use of corticotropin in ulcerative colitis is predicated on its effectiveness in reducing the extensive inflammatory tissue reaction that characterizes the disease and in diminishing the systemic and toxic manifestations of infection. Hormonal inhibition of fibroblastic proliferation with the possible prevention of fibrosis and stricture formation were additional indications. The dramatic increase in appetite and sense of well-being, which often characterize the administration of

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