Suppression of Acute and Chronic Rejection by Hepatocyte Growth Factor in a Murine Model of Cardiac Transplantation
- 21 September 2004
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 110 (12) , 1650-1657
- https://doi.org/10.1161/01.cir.0000143052.45956.71
Abstract
Background— Although treatment with immunosuppressive agents has contributed to overcoming acute rejection and improving the midterm survival of transplanted hearts, cardiac allograft vasculopathy (CAV) has remained the main cause of primary graft failure. Recent approaches have shown that hepatocyte growth factor (HGF) exhibits cardiotrophic functions. We therefore addressed whether HGF would regulate acute and chronic rejection in cardiac transplantation.Keywords
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