Use of Magnetic Nanoparticles as Nanosensors to Probe for Molecular Interactions
- 26 February 2004
- journal article
- concept
- Published by Wiley in ChemBioChem
- Vol. 5 (3) , 261-264
- https://doi.org/10.1002/cbic.200300730
Abstract
Biocompatible magnetic nanosensors have been designed to detect molecular interactions in biological media. Upon target binding, these nanosensors cause changes in the spin–spin relaxation times of neighboring water molecules, which can be detected by magnetic resonance (NMR/MRI) techniques. These magnetic nanosensors have been designed to detect specific mRNA, proteins, enzymatic activity, and pathogens (e.g., virus) with sensitivity in the low femtomole range (0.5–30 fmol).Keywords
This publication has 25 references indexed in Scilit:
- Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dotsNature Biotechnology, 2002
- Magnetic Nanosensors for the Detection of Oligonucleotide SequencesAngewandte Chemie International Edition in English, 2001
- Magnetic Nanosensors for the Detection of Oligonucleotide SequencesAngewandte Chemie, 2001
- Quantum-dot-tagged microbeads for multiplexed optical coding of biomoleculesNature Biotechnology, 2001
- Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic DetectionScience, 1998
- Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold NanoparticlesScience, 1997
- A DNA-based method for rationally assembling nanoparticles into macroscopic materialsNature, 1996
- Semiconductor Clusters, Nanocrystals, and Quantum DotsScience, 1996
- Kolloidale Halbleiter‐Q‐Teilchen: Chemie im Übergangsbereich zwischen Festkörper und MolekülAngewandte Chemie, 1993
- Colloidal Semiconductor Q‐Particles: Chemistry in the Transition Region Between Solid State and MoleculesAngewandte Chemie International Edition in English, 1993