The total synthesis of (–)-phyllanthostatin-1
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 1026-1028
- https://doi.org/10.1039/c39870001026
Abstract
The first total synthesis of the important antitumour glycoside (–)-phyllanthostatin-1 (1) is described; the key steps include a regioselective Koenigs–Knorr reaction to establish the 1,2-O-linkage in disaccharide (6) and a stereoselective triphenylphosphine–di-isopropyl azodicarboxylate (TPP–DIAD) glycosidation of hemiacetal (12) with aglycone (15).Keywords
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