Aminolysis of 2′-Deoxyinosine Aryl Ethers: Nucleoside Model Studies for the Synthesis of Functionally Tethered Oligonucleotides
- 1 December 1992
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 11 (10) , 1749-1763
- https://doi.org/10.1080/07328319208017821
Abstract
Several O6-aryl-2′-deoxyinosines were synthesized and found to undergo conversion to N6-substituted-2′-deoxyadenosines upon treatment with aqueous amines. The kinetics for reaction of these nucleosides with various amines suggests that O6-phenyl- and O6-(p-nitrophenyl)-2′-deoxyinosine are suitable “convertible nucleoside” precursors for the site-specific introduction of functionally tethered 2′-deoxyadenosines into DNA.Keywords
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