Genetic control of two different types of antibody responses to oxazolone

Publisher Website
Google Scholar
Abstract
The genetic control of antibody responses induced by contact sensitization with oxazolone and immunization with an oxazolone-mouse serum albumin conjugate was studied in inbred, H-2-congenic and nude mice. Both types of antibody responses are T cell-dependent and regulated by immune response genes mapping at the I-B subregion of the H-2 complex. The relative magnitude of antibody responses induced by the two methods of immunization is governed by a gene or genes mapping at the I-B subregion of the H-2 complex. Presentation of antigen by these two methods gives H-2-dependent distributions of high and low responsiveness which are exactly opposite. Non-H-2 genes affect the overall level of antibody response but not the relative magnitude of the responses.