Italian Multicenter Study on the Treatment of Chronic Obstructive Lung Disease with Bromhexine
- 1 January 1989
- journal article
- research article
- Published by S. Karger AG in Respiration
- Vol. 56 (1-2) , 11-15
- https://doi.org/10.1159/000195772
Abstract
237 out-patients suffering from chronic obstructive lung disease (COLD) were selected from 7 Italian clinical centers. They were randomly allocated to either placebo or bromhexine 30 mg b.i.d. p.o., in a double-blind fashion. Sputum volume and quality, facility of expectoration, cough, dyspnea, auscultatory thoracic symptoms, forced expiratory volume, peak expiratory now rate and residual volume were evaluated. Bromhexine showed a statistically significant therapeutic activity in comparison to placebo. This action was rapid, marked and effective in determining a modulation of bronchial secretions.Keywords
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