Relationship between the amounts of EBV‐DNA and ebna per cell, clonability and tumorigenicity in two EBV‐negative lymphoma lines and their EBV‐converted sublines

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Abstract
The effect of EBV‐conversion of two EBV‐negative lymphoma lines (Ramos and BJAB) on agarose clonability and tumorigenicity in nude mice was explored. The cloning frequency was increased in all 9 sublines investigated, between I.I and 4.9 times compared to the original “parental” lines. Tumorigenicity was increased in one out of 2 BJAB‐derived, EBV‐positive lines and in 3 of 6 Ramosderived lines, while it was decreased in 3 others. A strong positive correlation between the number of genomes/cell and the amount of EBNA/cell was detected, and in 7 of 9 converted lines the cloning frequency also correlated to the number of EBV genomes. On the other hand, no relation was established between the number of EBV‐genomes/cell, the amount of EBNA/cell and tumorigenicity.

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