Cutaneous biometrics I. The response of human skin to dimethyl sulphoxide

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Abstract
The wealing response of human skin to dimethyl sulfoxide (DMSO) was quantified. Concentrations of 90, 95 and 100% were applied for 5 min to circular areas 8 mm in diameter. Wealing was scored on a 5-point scale after 10 min. Marked individual variation was found. Wealing was strongly influenced by body region and was dose-dependent. The intensity of the reaction paralleled that of other irritants and was dependent on thickness and integrity of the horny layer. The DMSO test is a simple, quick way to assess the barrier function of the stratum corneum.