New molecular strategies to cure brain tumors.
Open Access
- 1 April 1999
- journal article
- review article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 56 (4) , 449-453
- https://doi.org/10.1001/archneur.56.4.449
Abstract
Overall, malignant primary and metastatic brain tumors remain as lethal in the 1990s as they were in the 1970s. Just as the introduction of radiation therapy 2 decades ago added several months to survival time, numerous chemotherapeutic trials have demonstrated only limited efficacy. Fortunately, recent discoveries in molecular medicine have not only revolutionized our understanding of the events that lead to tumorigenesis, but they have created novel tools for targeting malignant cells. Novel treatment modalities are now being tested in pre-phase I animal models, while others are in different stages of clinical trials. The purpose of this review is to briefly summarize the emerging strategies of gene therapy, antiangiogenesis, immunotherapy, and targeting tumor cells.Keywords
This publication has 21 references indexed in Scilit:
- Adenovirus-Mediated Gene Transfer to Treat Neurologic DiseaseArchives of Neurology, 1998
- Antiangiogenic therapy of experimental cancer does not induce acquired drug resistanceNature, 1997
- Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxiaOncogene, 1997
- Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor GrowthCell, 1997
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisPublished by Elsevier ,1996
- Angiostatin induces and sustains dormancy of human primary tumors in miceNature Medicine, 1996
- Priming of tumor-specific T cells in the draining lymph nodes after immunization with interleukin 2-secreting tumor cells: three consecutive stages may be required for successful tumor vaccination.Proceedings of the National Academy of Sciences, 1995
- Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutantNature, 1994
- In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain TumorsScience, 1992
- Lymphatics, Lymph and the Lymphomyeloid Complex.Joseph Mendel Yoffey , Frederick Colin CourticeThe Quarterly Review of Biology, 1972