Ethacrynic acid
- 25 November 1996
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 7 (18) , 2983-2988
- https://doi.org/10.1097/00001756-199611250-00037
Abstract
ETHACRYNIC acid (ETA) inhibits somatic CE-extrusion from hippocampal pyramidal neurones. We analysed the dependence of postsynaptic γ-aminobutyric acid (GABA) responses on this CF extrusion. ETA irreversibly reduced the 'somatic' hyperpolarizing GABAA response (hGABAA) within a few minutes, without altering the following depolarizing GABAA (dGABAA) and hyperpolarizing GABAB responses. GABA-induced changes of the membrane resistance were not affected by ETA, indicating that ETA does not act primarily on receptor-operated channels. In about 50% of the tested CA3 neurones spontaneous activity and caffeine-induced epileptiform discharges increased initially after adding ETA. All neurones lost their activity during prolonged ETA exposure. The early ETA-induced increase of neuronal activity coincided with the decrease of hGABAA (disinhibition). The late suppressive action may be caused by intracellular acidosis.Keywords
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