Serum Levels of CD8 Antigen and Soluble Interleukin 2 Receptors in Patients with B Cell Chronic Lymphocytic Leukemia
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 85 (2) , 57-61
- https://doi.org/10.1159/000204857
Abstract
We assayed the plasma levels of CD8 antigen (CD8Ag) and soluble interleukin 2 receptor (sIL-2R) in 34 subjects with B cell chronic lymphocytic leukemia (B-CLL) and in 15 controls using an immunoenzymatic method. The results showed higher average levels of soluble CD8 (sCD8) and sIL-2R in the leukemic patients compared to the controls (sCD8 = 860 vs. 306 U/ml; sIL-2R ≈ 4,131 vs. 311 U/ml). The two antigen levels were significantly higher in patients with progressive disease than in those with indolent disease, and they also correlated with Rai’s stage. sIL-2R levels correlated with lymphocyte count (pKeywords
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