CYTOLOGICAL METHODS FOR EARLY DETECTION OF UTERINE CANCER
- 9 February 1952
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 148 (6) , 457-459
- https://doi.org/10.1001/jama.1952.02930060039011
Abstract
The introduction of cytological methods for the early diagnosis of uterine cancer has been a significant modern development in spite of waning emphasis on the morphological approach to clinical problems. The emergence of the method was the logical outcome of two separate series of investigations—the introduction of the concept of noninvasive carcinoma by Rubin1and the perfection by Papanicolaou2of technical methods for studying cells exfoliated from the female genital tract. The principle on which the method rests derives from phenomena implicit in the observations of Coman,3namely, that the force required mutually to separate normal cervical cells is some 10 times that required to separate the cells of squamous carcinoma of the cervix. The usefulness of exfoliative cytologic studies in the early diagnosis of uterine cancer has been extensively studied during the past eight years. Several investigators4have convincingly documented its relative reliability, and L'EsperanceKeywords
This publication has 0 references indexed in Scilit: