CARDIAC AUTOMATISM AND CHOLINE ACETYLATION IN RATS ON THIAMINE- AND PANTOTHENIC- ACID-DEFICIENT DIETS

Publisher Website
Google Scholar
Abstract
The choline-acetylating activity of extracts of the acetone powders of hearts of rats fed on diets deficient in thiamine, in pantothenate, and in thiamin plus pantothenate was found to be the same as it was in rats on a complete synthetic diet, although severe changes in the electrocardiogram (ecg) were present in rats on the 2 thiamin-deficient diets. These ecg changes were the same as the ones described in rats on diets deficient in other factors besides thiamin. The rats on the pantothenic-acid-deficient diet grew as normals did and no ecg abnormalities were seen in them. The symptoms of thiamin deficiency were attenuated and their appearance delayed when pantothenate also was deleted from the diet.