Capsaicin-sensitive mechanisms and experimentally induced duodenal ulcers in rats
- 1 July 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 39 (7) , 559-561
- https://doi.org/10.1111/j.2042-7158.1987.tb03179.x
Abstract
The incidence and degree of cysteamine‐ or dulcerozine‐induced duodenal ulcers are increased by systemic capsaicin desensitization (50 mg kg−1 s.c. 4 days before) in adult rats. Acute administration of capsaicin, but not neurokinins or CGRP, produced a small but distinct plasma extravasation (Evans blue leakage) in the rat proximal duodenum which was absent in capsaicin‐pretreated rats. These findings indicate the existence of a capsaicin‐sensitive ‘duodenal defence mechanism’ in rats.This publication has 18 references indexed in Scilit:
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