MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain
Open Access
- 13 June 2003
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 50 (1) , 201-205
- https://doi.org/10.1002/mrm.10511
Abstract
Stem cell transplantation is being explored as a new paradigm for the treatment of demyelinating diseases. Magnetically labeled multipotential neural precursor cells were transplanted into the ventricles of rats with acute experimental allergic encephalomyelitis (EAE) and high‐resolution (microscopic) MR images were obtained ex vivo. Migration patterns of live cells into periventricular white matter structures could be easily visualized, with a good correlation of the corresponding histopathology. The present results confirm that MR cell tracking can be used to guide the development of successful transplantation protocols. Magn Reson Med 50:201–205, 2003.Keywords
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