The Effect of Tubal Ligation on Ovarian Function in the Rat.

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Abstract
Young healthy female rats with normal estrous cycles with simple bilateral tubal ligation proximal to the uterus show prolonged periods of estrus. When the distended capsule produced by this procedure is removed, the animals resume normal cycles. The fluid obtained from the capsule contains estrogens. The histological changes in the ovaries after 30 days of tubal ligation are marked follicle stimulation and lack of corpus luteum formation. After 90 days of tubal ligation the ovaries become cystic, probably due to a progressive inadequacy of blood supply.

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