Constituents of the leaves of Woodfordia fruticosa Kurz. I. Isolation, structure, and proton and carbon-13 nuclear magnetic resonance signal assignments of woodfruticosin (woodfordin C), an inhibitor of deoxyribonucleic acid topoisomerase II.
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (10) , 2687-2697
- https://doi.org/10.1248/cpb.38.2687
Abstract
Woodfruticosin (woodfordin C), a new cyclic dimeric hydroyzable tannin having an inhibitory activity toward deoxyribonucleic acid (DNA) topoisomerase II, has been isolated from the leaves of Woodfordia fruticosa Kurz (Lythraceae) along with known flavonol glycosides andd three known flavonol glycoside gallates. The structure of woodfruticosin (woodfordin C) was determined by the use of two-dimensional nuclear magnetic resonance (2-D NMR) spectroscopy including heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC) techniques. Detailed analyses of the proton and carbon-13 NMR (1H and 13C-NMR) spectra of six known flavonoids were performed.This publication has 4 references indexed in Scilit:
- Complete proton and carbon-13 assignments of coenzyme B12 through the use of new two-dimensional NMR experimentsJournal of the American Chemical Society, 1986
- Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer ChemotherapyPublished by Elsevier ,1986
- A homogeneous type II DNA topoisomerase from HeLa cell nuclei.Journal of Biological Chemistry, 1981
- Carbon-13 NMR studies of flavonoids—IIITetrahedron, 1978