TISSUE CHANGES IN CHRONIC EXPERIMENTAL LYMPHOEDEMA IN DOGS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 13  (3) , 130-141
Abstract
Chronic lymphedema was experimentally induced in the legs of dogs and studied with the EM. Some cells (macrophages, fibroblasts and to a lesser extent, lymphocytes) increased greatly in numbers and relative volumes. Collagen and fat cells greatly increased in relative volume. The lengths of blood vessels and initial lymphatics were greater in injured tissue. The numbers of small vesicles and vacuoles rose in both types of vessels. Both also had many open endothelial junctions, probably from different causes. Chronic inflammation is probably caused by excessive protein accumulations. Chronic lymphedema is probably a form of chronic inflammation.