STUDIES ON EXPERIMENTAL SHOCK IN DOGS

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Abstract
A method is described for producing shock in dogs by application of pressure cuffs to the hind legs. The blood pressure rose when the cuffs were applied and remained high during the period of application. When the cuffs were removed the blood pressure fell. The average survival time of 34 dogs was three hours, 20 min. Among the changes noted were an increase in haematocrit value, a rise in the lactic acid concentration in the femoral vein, and a rapid decrease in the oxygen content of jugular vein blood with maintenance of the arterial oxygen content until shortly before death. The plasma protein concentration usually rose but was variable.The intermittent application of pressure cuffs, using 20 min. periods of application with five minute release intervals, produced no serious effects, but with 40 min. periods of application signs of shock developed. When haemorrhage preceded the application of cuffs for the 20 min. periods, recovery usually occurred but when the haemorrhage preceded the 40 min. periods, death resulted.Re-application of narrow band tourniquets to the injured legs of the shocked dogs produced an increase in blood pressure and an alleviation of their condition With compression of one leg for 10 hr. the changes in total limb volume and haematocrit value were similar to those obtained when both legs were compressed for five hours. The dogs with one cuff applied for 10 hr. survived while those with two cuffs applied for five hours did not. It is felt that fluid loss alone does not account for all the changes observed in these experiments.

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