The effects of antidiuretic hormone and state of potassium balance on the renin‐angiotensin system in rats with diabetes insipidus.

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Abstract
The influence of ADH [antidiuretic hormone] and the state of K balance on the renin-angiotensin system was studied in rats with hereditary diabetes insipidus (DI rats). Plasma renin concentration in DI rats was higher than in control Long-Evans rats. Spontaneous reversal of the hypokalemia normally found in DI rats did not reduce plasma renin concentration (PRC), suggesting that K deficiency does not contribute significantly to the elevation of PRC in DI rats. Similarly, a low K diet failed to further increase PRC in DI rats. The PRC of DI rats was significantly diminished by a high K intake both in the presence and absence of ADH. A highly significant inverse correlation was found between PRC and urinary K excretion in both ADH-treated and untreated DI rats on low, normal and high K diets. Plasma renin concentration was significantly lower in ADH-treated than in untreated DI rats on a high K intake, suggesting that the inhibitory effects of ADH and K are additive. ADH consistently reduced PRC in DI rats, independent of the state of K balance. ADH and K may inhibit renin secretion via different mechanisms of action.