The K101P and K103R/V179D Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nonnucleoside Reverse Transcriptase Inhibitors
Open Access
- 1 January 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (1) , 351-354
- https://doi.org/10.1128/aac.50.1.351-354.2006
Abstract
Genotypic patterns associated with nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance in the absence of well-characterized resistance mutations were identified using a database (n> 47,000) of phenotype-genotype data. Among samples with no known NNRTI mutations, the most resistant samples contained K101P (n= 35) or a combination of K103R and V179D (n= 41). Site-directed mutagenesis confirmed the importance of these mutations.Keywords
This publication has 18 references indexed in Scilit:
- Analysis of discrepancies in the interpretation of antiretroviral drug resistance results in HIV-1 infected patients of Basque Country, SpainJournal of Clinical Virology, 2005
- Rare mutations at codon 103 of HIV-1 reverse transcriptase can confer resistance to non-nucleoside reverse transcriptase inhibitorsAIDS, 2005
- Treatment for Adult HIV InfectionJAMA, 2004
- Natural Variation of Drug Susceptibility in Wild-Type Human Immunodeficiency Virus Type 1Antimicrobial Agents and Chemotherapy, 2004
- Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus ReplicationJournal of Virology, 2003
- Phenotypic and Genotypic HIV-1 Drug Resistance Assays Provide Complementary InformationJAIDS Journal of Acquired Immune Deficiency Syndromes, 2002
- Genotypic Testing for Human Immunodeficiency Virus Type 1 Drug ResistanceClinical Microbiology Reviews, 2002
- Discordance between Genotypic and Phenotypic Drug Resistance Profiles in Human Immunodeficiency Virus Type 1 Strains Isolated from Peripheral Blood Mononuclear CellsJournal of Clinical Microbiology, 2002
- L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptaseAntimicrobial Agents and Chemotherapy, 1995
- Mutational Analysis of Residue 190 of Human Immunodeficiency Virus Type 1 Reverse TranscriptaseVirology, 1994