Comparative analysis of the cytotoxicity of substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper(II) chelates. 2. Parabolic correlations and their implications for selective toxicity

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Abstract
An extended series of para-substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper(II) chelates was synthesized. Biological evaluation and regression analysis was performed, correlating pI50 [the negative logarithm of the molar concentration giving 50% inhibition] with extrathermodynamic substituent parameters. Parabolic correlations with .pi. [Hansch hydrophobic substituent constant] resulted, which predict optimum lipophilic character of the para substituent with respect to [mouse] Ehrlich ascites cytotoxicity (.pi.o = 2.13) and with respect to [mouse] ascites vs. [rat] liver slice cytotoxicity (.pi.o = -1.31). The chelate most toxic to the tumor cell model may not be the most selective.