Induction of leukemia in rat by pulse doses of 7,12-dimethylbenz(a)anthracene.
- 1 January 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 55 (1) , 74-81
- https://doi.org/10.1073/pnas.55.1.74
Abstract
Multiple pulse doses of 7,12-dimethylbenz (a) anthracene, under stated conditions, induce leukosis in every rat; in most of the animals leukosis is followed by leukemia which is transplantable to newborn rats of the same strain. Whereas several types of leukemia are evoked, the predominant type is a stem-cell leukemia which has a predilection for growth in liver and is usually associated with erythroblastosis. Presence of thymus and spleen is not obligatory for aromatic induction of this type of leukemia.This publication has 8 references indexed in Scilit:
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