Stability of Nonionic Water-soluble Contrast Media
- 1 November 1980
- journal article
- research article
- Published by Wolters Kluwer Health in Investigative Radiology
- Vol. 15, S323-S328
- https://doi.org/10.1097/00004424-198011001-00068
Abstract
The stability of the nonionic contrast media metrizamide, P-297, iopamidol, and nonionic phenyl ether DS-1-132 was studied by exposing their aqueous solutions to 120 C. Metrizamide showed decomposition of the sugar residue, while in P-297 the sugar substituent was cleaved off the triiodoaniline moiety. Iopamidol and DS-1-132 showed no decomposition. For stability, sugar moieties should be attached either by an ether linkage or as amides, as long as the acylamino group is not on a carbon adjacent to the anomeric carbon. Polyhydroxyalkylamines are less hydrophilic but more stable than sugars.Keywords
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