THE INFLUENCE OF THE FOODSTUFFS UPON THE SUSCEPTIBILITY OF THE LIVER TO INJURY BY CHLOROFORM, AND THE PROBABLE MECHANISM OF THEIR ACTION 12

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Abstract
Hepatic cellular damage increases progressively with an increase in the conc. of hepatic lipid; this is explainable by the hypothesis suggested by Wells. A high conc. of hepatic glycogen, per se, does not protect against the hepatoxic action of chloroform. High carbohydrate diets probably protect the liver by reducing the lipid content of the liver or under certain conditions by sparing protein. High protein diets are markedly protective; this is best explained as due to increased amts. of protein available to the liver which serves either to protect it against injury or for rapid regeneration pari passu with the injury. The marked susceptibility of starved rats is probably due principally to its depleted protein stores.