The Role of the Spleen in the Leukocytosis Following the Intra-arterial Administration of Epinephrine

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Abstract
The injn. of 0.2-0.3 mg. of epinephrine directly into the splenic artery of man was followed by a leukocytosis in the hepatic vein and pulmonary artery in about 120-260 sec. and persisted for about 3 min. Both granulocytes and non-granulocytes were involved but not platelets. A similar response followed injn. of epinephrine into a distant artery. Leukocytosis, primarily granulocytic, appeared in the peripheral blood in 30-60 sec. The number of platelets increased in the arterial blood more than in the venous blood.