FACTORS INFLUENCING CADMIUM MOBILIZATION BY DIETHYLDITHIOCARBAMATE - CHELATOR DOSE, CADMIUM BURDEN, AND SEX

  • 1 January 1983
    • journal article
    • research article
    • Vol. 13  (2) , 107-114
Abstract
A study was made of the effects of diethyldithiocarbamate (DDTC) [an antidote for heavy metal poisoning] on organ distribution and excretion of Cd as influenced by DDTC dose, Cd burden and sex of mice. DDTC [100-250 mg/kg] did not promote mobilization of hepatic Cd, but it was effective at 500 mg/kg. All doses tested were significantly effective in mobilizing renal and splenic Cd, and the response was dose-dependent, as was the increase in brain levels of Cd. Cd mobilization by DDTC following Cd loads over a 3-fold range appeared to be 1st order in nature; i.e., a given regimen of DDTC treatment promoted mobilization of a virtually constant percentage of the Cd administered, rather than a constant amount of Cd. The response to DDTC was markedly sex-dependent, being more effective in females than males. In organs of control Cd-loaded mice, 1 sex-related difference was noted; spleens of females retained a considerably greater percentage of administered Cd than those of males.

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