Peptic ulcer pathogenesis

Publisher Website
Google Scholar
Abstract
In the absence of non-steroidal anti-inflammatory drugs pathogenesis of peptic ulceration is multifactorial with Helicobacter pylori and gastric acid as equally the most important and the most likely steps in a cascade of events, starting with H. pylori infection during childhood and resulting in the outbreak of the disease years to decades later. One important cofactor in the pathogenesis of duodenal ulceration is gastric metaplasia, with gastric acid as predisposing factor and H. pylori as modulator of size and of the extent of inflammation. There has been considerable progress in our understanding of how H. pylori contributes to the well known gastric acid hypersecretion, to basal and postprandial hypergastrinaemia, to the severity of inflammation of antral metaplasia in the duodenal bulb, and thus to the predisposition for ulcer formation.

This publication has 0 references indexed in Scilit: