Prevention of chromosomal breakage in Fanconi's anemia by cocultivation with normal cells
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 56 (2) , 169-171
- https://doi.org/10.1007/bf00295689
Abstract
The frequency of aberration in cultured lymphocytes from patients with Fanconi's anemia was significantly reduced when the cells were cocultivated with normal human lymphocytes. The results suggest that most of the chromosomal aberrations observed in cultured cells from Fanconi patients arise during cultivation and that the presence of normal cells prevents chromosomal damage by means of a hitherto unknown mechanism.Keywords
This publication has 13 references indexed in Scilit:
- Effect of superoxide dismutase and catalase on spontaneously occurring chromosome breaks in patients with Fanconi's anemiaHereditas, 2009
- ERYTHROCYTE SUPEROXIDE-DISMUTASE DEFICIENCY IN FANCONI'S ANÆMIAThe Lancet, 1978
- Localization of chromatid breaks in Fanconi's anemia, using three consecutive stainsHuman Genetics, 1977
- Progeria cells are stimulated to repair DNA by co-cultivation with normal cellsExperimental Cell Research, 1976
- Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?Nature, 1975
- The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblastsHuman Genetics, 1975
- Frequency and distribution of sister-chromatid exchanges in a case of Fanconi's anemiaHuman Genetics, 1975
- Nonrandom distribution of chromosome breaks in Fanconi’s anemiaCytogenetic and Genome Research, 1973
- PREANÆMIC STATE IN FANCONI'S ANÆMIAThe Lancet, 1967
- Leukocytes Cultured from Small Inocula of Whole Blood and the Preparation of Metaphase Chromosomes by Treatment with Hypotonic KCLStain Technology, 1965