Low Incidence of a Nucleotide Sequence Alteration of the Neurofibromatosis 2 Gene in Human Breast Cancers
- 1 October 1995
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 86 (10) , 929-933
- https://doi.org/10.1111/j.1349-7006.1995.tb03003.x
Abstract
We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single‐strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor‐specific single‐base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.Keywords
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