Antimalarial Activity of a Riboflavin Analog against Plasmodium vinckei in Vivo and Plasmodium falciparum in Vitro

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Abstract
The riboflavin analog 10-(4′-chlorophenyl)-3-methylflavin was found to have significant activity against Plasmodium vinckei vinckei when administered orally and parenterally; it was active against P. falciparum in culture. It inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. When administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against P. falciparum in vitro.